In molecular biology mir-671 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
Alcoholic and Non-Alcoholic Fatty Liver Disease
miR-671 expression levels have been found to be vary significantly between the alcoholic and non-alcoholic forms of fatty liver disease.
CDR1 regulation
miR-671 has been seen to negatively regulate the CDR1 (Cerebellar Degeneration-Related protein 1) gene, through the targeting and cleavage of a circular antisense transcript of the CDR1 locus. There is a partnered decrease in CDR1 mRNA levels with this downregulation.
FN1 repression
miR-671 is able to bind to and repress fibronection type 1 (FN1) mRNA at its 3'untranslated region binding site.
See also
- MicroRNA
References
Further reading
- Hou, Q.; Huang, J.; Ju, Z.; Li, Q.; Li, L.; Wang, C.; Sun, T.; Wang, L.; Hou, M.; Hang, S.; Zhong, J. (2012). "Identification of Splice Variants, Targeted MicroRNAs and Functional Single Nucleotide Polymorphisms of theBOLA-DQA2Gene in Dairy Cattle". DNA and Cell Biology. 31 (5): 739–744. doi:10.1089/dna.2011.1402. PMC 3358092. PMID 22084936.
External links
- Page for mir-671 microRNA precursor family at Rfam
